| NBRP Rat No | 0001 |
|---|---|
| 品系 名稱 | ACI/NKyo |
| 俗名 | August Copenhagen Irish |
| 毛色 | agouti (A,B,hi) |
| 近交系世代 | F143+73 (March 2012) |
| Genetic Status | Inbred |
| 應用 | 生殖(Reproduction) |
| 來源 | 1988年，F143從NIH引進到京都大學醫學院附屬動物實驗設施。 |
| 特徵 | 約 10-20% 的 ACI 大鼠出現單一腎(unilateral renal agenesis)、發育不全(hypoplasia)或囊性腎水腫(cystic hydronephrosis)。 受影響的個體表現出雌性同側子宮角缺失(ipsilateral uterine horn)，雄性睪丸缺失或發育不全。 |
| 繁殖狀態 | 兄妹交配。良好的繁殖性，但在極少數情況下，由於單側子宮角缺陷，後代數量較少。 |
Reference 參考文獻
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Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.
Int Immunol. 2018 Jan 18. [Epub ahead of print] - Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
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PLoS One. 2012;7(8):e43059. - Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T.
A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.
BMC Genetics 12:91, 2011 - Matsuno K, Ueta H, Shu Z, Xue-Dong X, Sawanobori Y, Kitazawa Y, Bin Y, Yamashita M, Shi C.
The microstructure of secondary lymphoid organs that support immune cell trafficking.
Arch Histol Cytol. 2010;73(1):1-21. Review. - LinksShull JD, Lachel CM, Strecker TE, Spady TJ, Tochacek M, Pennington KL, Murrin CR, Meza JL, Schaffer BS, Flood LA, Gould KA.
Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14.
Mamm Genome. 17(7):751-9, 2006.
