| NBRP Rat No | 0011 |
|---|---|
| 品系名稱 | ACI/NKyo |
| 俗名 | ACI/NKyo |
| 毛色 | tan hooded (a,B,C,h,p,R) |
| 近交系世代 | F18+29 (March 2012) |
| Genetic Status | Inbred, Spont. Mutant |
| 應用 | 眼科(Ophthalmology) |
| Gene Affected | Mertk: c-mer proto-oncogene tyrosine kinase |
| 來源 | 在1938年，在一隻帶有粉紅色眼睛的有色大鼠中，發現遺傳性視網膜異常的個體(Bourne, 1983)。於1998年從京都大學醫學部眼科學教室搬遷至京都大學醫學研究科附屬動物實驗設施。RCS是Royal College of Surgeons的縮寫。（2010年10月1日） |
| 特徵 | 視網膜障礙。人類視網膜色素病變(retinitis pigmentosa)的模型動物。 其致病基因rdy (視網膜失養症, retinal dystrophy)是由於encode 酪氨酸激酶受體(tyrosine kinase receptor)的Mertk基因的刪除突變所致（D'Cruz, 2000）。視網膜障礙從3週齡起開始逐步發展（Bourne, 1938）。通常，感光細胞之一的視桿細胞的外節（outer segment）會被色素上皮細胞吞噬和再生。但在RCS大鼠，色素上皮細胞的吞噬功能受到損害。 因此，未被分解的視桿細胞外節片段會堆積，視桿細胞和視錐細胞經歷細胞凋亡（Dowling, 1962; Tuo, 1994）。已有多項針對光受體細胞進行性退化的治療實驗被報道（Faktorovich, 1990; Zhang, 2009; Thumann, 2009; Lu, 2010）。 粉紅眼稀釋：此突變在Oca2 (又名P)有刪除突變，並呈現淺粉紅色眼睛。 |
| 繁殖狀態 | 兄妹交配。良好的繁殖性。 |
Reference 參考文獻
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