- 品系 | NC
- BRC No.: | RBRC01059
- 毛色 | 鼠栗色 棕色 agouti brown [A/A b/b C/C D/D S/S]
來源
由名古屋大學農學院的Dr. Kyoji Kondo at Nagoya開發。來自日本fancy mice (Nishiki-Nezumi) 的肉桂色毛色族群。
描述
NC/Nga小鼠源於日本fancy mice (Nishiki-Nezumi)，並於1955年建立為一個近交系品系。當這些小鼠在一般環境下飼養時，會發展出類似於異位性皮膚炎(atopic dermatitis)的皮膚病變，但在無特定病原環境下（SPF）飼養時則不會。此品系對X射線輻射和卵清蛋白(ovalbumin)引起的過敏性休克(anaphylactic shock)有高度敏感性。
族群維持
同胞交配(Sibling Mating)
基因
Gene symbol: Derm1
Gene name: dermititis 1
Chr.: 9
Allele symbol: Derm1
Allele name: NC/Nga
研究應用
皮膚病學研究
Publications：
- Chiu YH, Wu YW, Hung JI, Chen MC.
Epigallocatechin gallate/L-ascorbic acid-loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis.
Acta Biomater 130 223-233(2021) 34087444 - Chen MC, Chen CS, Wu YW, Yang YY.
Poly-γ-Glutamate microneedles as transdermal immunomodulators for ameliorating atopic dermatitis-like skin lesions in Nc/Nga mice.
Acta Biomater 114 183-192(2020) 32688089 - F Zhuo, MAS Abourehab, Z Hussain.
Hyaluronic Acid Decorated Tacrolimus-Loaded Nanoparticles: Efficient Approach to Maximize Dermal Targeting and Anti-dermatitis Efficacy.
Carbohydrate Polymers () - Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E, Buang F, Sahudin S.
Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: an ex vivo and in vivo study using an NC/Nga mouse model.
Int J Pharm 444(1-2) 109-19(2013) 23337632 - Hussain Z, Katas H, Amin MC, Kumulosasi E, Sahudin S.
Antidermatitic perspective of hydrocortisone as chitosan nanocarriers: an ex vivo and in vivo assessment using an NC/Nga mouse model.
J Pharm Sci 102(3) 1063-75(2013) 23303620 - Knitlova J, Hajkova V, Voska L, Elsterova J, Obrova B, Melkova Z.
Development of eczema vaccinatum in atopic mouse models and efficacy of MVA vaccination against lethal poxviral infection.
PLoS One 9(12) e114374(2014) 25486419 - Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E.
Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitrofluorobenzene-induced atopic dermatitis: nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs.
PLoS One 9(11) e113143(2014) 25396426 - Yang Z, Liu M, Wang W, Wang Y, Cao B, Gao Y, Chen H, Li T.
Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation.
Sci Rep 7(1) 7918(2017) 28801611
