A congenic strain with the genetic background of the BB/WorTky strain (RT1.Bu,Du) onto which the MHC locus of PVG.R23 strain (RT1.Ba,Da) has been transferred.
Strain characteristics
Animals carrying u/u alleles of the MHC locus show diabetes and animals carrying a/a alleles show thyroiditis.
Breeding Conditions
Maintained by crossing heterozygotes u/a allele of the MHC locus.
Genotyping
PCR-RFLP
References
Awata T, Guberski DL, Like AA.
Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II.
Endocrinology. 1995 Dec;136(12):5731-5.