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Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  F71+9+15 (09.5.29)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected  
Origin Lewis rats: Tokyo Medical Insitute -> Seiwa Institute of Experimental Animals, Hydrocephalus was found the rats at F27 in 1980 -> Dr. Yasutaka Noda at Center for Animal Experiments, Kurume University, The hydrocephalus rat strains have been maitained out by selective breeding.
Strain characteristics Congenital hydrocephalus. Appearance of hydocephalus rats: about 33% in males, about 13 % in females.
Breeding Conditions For an optimal breeding performance, 20% of the colony should develop hydrocephalus. Selection for higher disease occurrence reduces breeding efficiency due to infertle animals.
Genotyping  
References ・小児の脳神経9(4):257-264,1984 ラットにおける先天性水頭症の実験モデル
・脳神経37(11):1053-1057,1985 先天性水頭症ラット(LEW/Jms)における脳組織障害について
・小児の脳神経12(1):1-9,1987 先天性水頭症ラット脳の病理学的観察
・脳神経42(6):539-545,1990 先天性水頭症ラット脈絡叢における心房性ナトリウム利尿ペプチド受容体の変動
Additional strain information LEW   

 
 
 
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