Lewis rats: Tokyo Medical Insitute -> Seiwa Institute of Experimental Animals, Hydrocephalus was found the rats at F27 in 1980 -> Dr. Yasutaka Noda at Center for Animal Experiments, Kurume University, The hydrocephalus rat strains have been maitained out by selective breeding.
Strain characteristics
Congenital hydrocephalus. Appearance of hydocephalus rats: about 33% in males, about 13 % in females.
Breeding Conditions
For an optimal breeding performance, 20% of the colony should develop hydrocephalus. Selection for higher disease occurrence reduces breeding efficiency due to infertle animals.